Food and Kidneys

Recent evidence suggests that fructose and modern diet contribute significantly to the development and worsening of chronic kidney disease.

Fructose and Chronic Kidney Disease [See]

Kretowicz M, Johnson RJ, Ishimoto T, Nakagawa T, Manitius J. The Impact of Fructose on Renal Function and Blood Pressure. International Journal of Nephrology. 2011, Article ID 315879, 5 pages. Available at

Johnson RJ, Sanchez-Lozada LG, Nakagawa T. The Effect of Fructose on Renal Biology and Disease. JASN. December 2010;21(12):2036-2039. DOI: Available at

Bratoeva K, Stoyanov GS, Merdzhanova A, Radanova M. Manifestations of Renal Impairment in Fructose-induced Metabolic Syndrome. Cureus. 2017;9(11):e1826. Published 2017 Nov 7. doi:10.7759/cureus.1826. Available at

Metabolic Syndrome Increases Risk of Kidney Disease: MetS and its components are associated with the development of eGFR <60 ml/min per 1.73 m2 and microalbuminuria or overt proteinuria, a meta analysis shows. [Thomas G et al. Metabolic Syndrome and Kidney Disease: A Systematic Review and Meta-analysis. CJASN August 2011 CJN.02180311. Abstract]

Gout Linked to Increased Risk for Diabetes, Renal Disease [See]

Western Style Diets Linked to Kidney Dysfunction: According to a study published in the American Journal of Kidney Diseases, Western diet is associated with a greater likelihood of the development of microalbuminuria (excretion of small amounts of albumin to the urine) and rapid decrease in kidney function, whereas diets similar to the Dietary Approach to Stop Hypertension (DASH) diet may be protective against rapid decline of estimated glomerular filtration rate (eGFR). [Abstract from American Journal of Kidney Diseases February 2011;57(2):245-254 | Report]

Metabolic syndrome increases kidney stone risk: Data from 34,895 individuals who underwent general health screening tests has revealed that kidney stones were 25% more likely to be found in subjects with metabolic syndrome than in those without it and that kidney stones were 47% more likely to be found in subjects with hypertension than in those without it. [In Gab Jeong et al. Association Between Metabolic Syndrome and the Presence of Kidney Stones in a Screened Population. AJKD. Article in press. Abstract]

Low Carbohydrate Diet May Reverse Kidney Failure in People With Diabetes: Researchers from Mount Sinai School of Medicine have for the first time determined that a specialized high-fat, low carbohydrate diet may reverse impaired kidney function in people with Type 1 and Type 2 diabetes. [Poplawski MM, Mastaitis JW, Isoda F, Grosjean F, Zheng F, et al. Reversal of Diabetic Nephropathy by a Ketogenic Diet. PLoS ONE 2011;6(4):e18604. doi:10.1371/journal.pone.0018604 Full Text | Older Study | Report | Report]

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