PCOS

Polycystic ovary syndrome (PCOS) is the commonest cause of infertility, characterised by excessive ovarian activity, yet non-development of healthy ova. Recent studies have clearly established its association with insulin resistance and other manifestations of metabolic syndrome, such as obesity, NAFLD, impaired glucose tolerance etc. Dietary restrictions can help in reversing PCOS within a few weeks.

Possible pathophysiological mechanisms of polycystic ovary syndrome [See]

Rocha AL, Oliveira FR, Azevedo RC et al. Recent advances in the understanding and management of polycystic ovary syndrome. F1000Research 2019;8(F1000 Faculty Rev):565 https://doi.org/10.12688/f1000research.15318.1 Available at https://f1000research.com/articles/8-565

Spinedi E, Cardinali DP. The Polycystic Ovary Syndrome and the Metabolic Syndrome: A Possible Chronobiotic-Cytoprotective Adjuvant Therapy. International Journal of Endocrinology. 2018, Article ID 1349868, 12 pages, 2018. https://doi.org/10.1155/2018/1349868. Available at https://www.hindawi.com/journals/ije/2018/1349868/

Shi B, Feng D, Sagnelli M et al. Fructose levels are elevated in women with polycystic ovary syndrome with obesity and hyperinsulinemia. Human Reproduction. January 2020;35(1):187–194. https://doi.org/10.1093/humrep/dez239

Mavropoulos JC, Yancy WS, Hepburn J, Westman EC. The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: a pilot study. Nutr Metab (Lond). 2005;2:35. Published 2005 Dec 16. doi:10.1186/1743-7075-2-35. Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1334192/

Zhang X, Zheng Y, Guo Y, Lai Z. The Effect of Low Carbohydrate Diet on Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials. Int J Endocrinol. 2019;2019:4386401. Published 2019 Nov 26. doi:10.1155/2019/4386401. Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899277/

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