Hypertension

Hypertension, termed as ‘essential’ in the literature, is increasing in prevalence and affecting more and more of younger population. Traditionally blamed on high consumption of slats, hypertension is increasingly being seen as a part of metabolic syndrome, associated with hyperuricemia, driven by modern day diet that is rich in sugars such as fructose.

Hypertensive mechanisms of fructose [See]

DiNicolantonio JJ, Lucan SC.The wrong white crystals: not salt but sugar as aetiological in hypertension and cardiometabolic disease. Open Heart 2014;1:e000167. doi: 10.1136/openhrt-2014-000167. Available at https://openheart.bmj.com/content/1/1/e000167

Rosset R, Surowska A, Tappy L. Pathogenesis of Cardiovascular and Metabolic Diseases: Are Fructose-Containing Sugars More Involved Than Other Dietary Calories?. Curr Hypertens Rep 2016;18:44. https://doi.org/10.1007/s11906-016-0652-7. Available at https://link.springer.com/article/10.1007/s11906-016-0652-7

Sugar Consumption Increases Blood Pressure: The recently published INTERMAP study reveals that soft drinks, sweetened fruit juices, and sugar-loaded sports drinks are associated with significant increases in systolic and diastolic blood pressures. [Abstract from Brown IJ, Stamler J, Van Horn L, et al. Sugar-sweetened beverage, sugar intake of individuals and their blood pressure: INTERMAP study. Hypertension Feb 2011. doi: 10.1161/HYPERTENSIONAHA.110.165456 | Report]

High fructose intake in the form of added sugar is independently associated with higher blood pressure, according to the results of a cross-sectional analysis of data from the National Health and Nutrition Examination Survey [Diana I. Jalal, Gerard Smits, Richard J. Johnson and Michel Chonchol. Increased Fructose Associates with Elevated Blood Pressure. Journal of the American Society of Nephrology. July 1, 2010. doi: 10.1681/ASN.2009111111] [Full text] | Report]

Fructose (Fruits) and High Blood Pressure Abstract of Carlos A. Roncal et al, Am J Nephrol; Reuters Report

Malik VS, Hu FB. Fructose and Cardiometabolic Health. Journal of the American College of Cardiology. 2015;66(14):1615-1624. doi: 10.1016/j.jacc.2015.08.025 Available at https://www.jacc.org/doi/abs/10.1016/j.jacc.2015.08.025

Hieronimus B, Medici V, Bremer AA. Synergistic effects of fructose and glucose on lipoprotein risk factors for cardiovascular disease in young adults. Metabolism. November 2020;112:154356. Available at https://www.sciencedirect.com/science/article/pii/S0026049520302201

Zhang D-M, Jiao R-Q, Kong LD. High Dietary Fructose: Direct or Indirect Dangerous Factors Disturbing Tissue and Organ Functions. Nutrients 2017;9(4):335. https://doi.org/10.3390/nu9040335 Available at https://www.mdpi.com/2072-6643/9/4/335/htm

Salt a key player in resistant hypertension Abstract in Pimenta E et al., Hypertension, 20 July, 2009; Report

Exclusive Breastfeeding helps to Boost IQ, has Favourable Effects on Height, Weight and Blood Pressure: Largest Prospective Study Finds Breastfeeding and Child Cognitive Development: New Evidence From a Large Randomized Trial; Effects of prolonged and exclusive breastfeeding on child height, weight, adiposity, and blood pressure at age 6.5 y: evidence from a large randomized trial; Effects of Prolonged and Exclusive Breastfeeding on Child Behavior and Maternal Adjustment: Evidence From a Large, Randomized Trial; Reports 1; 2; 3

Cut Down Salt Intake: ASH Position Paper – Dietary Approaches to Lower Blood Pressure
Full Text of Lawrence J. Appel, ASH; Medscape Article

Reduction of body fat more important than fitness in lowering blood pressure: Individuals who have a healthy body weight are more likely than those who are physically fit to have lower blood pressure, shows a new study [Chen J, Das S, Barlow CE, Grundy S, Lakoski SG. Fitness, fatness, and systolic blood pressure: data from the Cooper Center Longitudinal Study. Am Heart J. 2010 Jul;160(1):166-70.] [Abstract] | Report]

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