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Further Reading
Updated Jan 31, 2008
 
  1. Sergey Komarov. Mankind Is Predisposed To Diseases Of Civilization. At http://www.medicalnewstoday.com/articles/29755.php

  2. Moss RW. Cancer: A Disease of Civilization? At http://www.newagejournal.com/moss.shtml

  3. Ten S, Maclaren N. Insulin Resistance Syndrome in Children. JCEM 89(6):2526-2539 At http://jcem.endojournals.org/cgi/content/full/89/6/2526
  4. Obesity, Insulin Resistance, Diabetes, and Cardiovascular Risk in Children. Circulation. 2003;107:1448. At http://circ.ahajournals.org/cgi/content/full/107/10/1448
  5. Misra A, Vikram NK.  Insulin resistance syndrome (metabolic syndrome) and Asian Indians. Current Science 2002;83(12) At http://www.ias.ac.in/currsci/dec252002/1483.pdf
  6. Rand JS et al. Canine and Feline Diabetes Mellitus: Nature or Nurture? J. Nutr. 2004;134:2072S-2080S At http://jn.nutrition.org/cgi/content/full/134/8/2072S
  7. Martin FIR et al. Diabetes mellitus in urban and rural communities in Papua New Guinea. Diabetologia. 1980;18(5)
  8. Friedman JM Leptin, leptin receptors, and the control of body weight. Nutr Rev. 1998 Feb;56(2 Pt 2):s38-46; discussion s54-75
  9. Chan SJ,  Steiner DF. Insulin through the ages: Phylogeny of a growth promoting and metabolic regulatory hormone. American Zoologist  Apr 2000  At http://www.findarticles.com/p/articles/mi_qa3746/is_200004/ai_n8899929
  10. Ferrannini E et al. Insulin: new roles for an ancient hormone. Eur J Clin Inv 1999;29(10):842-852(11)
  11. Hardie DG, Hawley SA, Scott JW. AMP-activated protein kinase - development of the energy sensor concept J Physiol 574.1 pp 7-15 At http://jp.physoc.org/cgi/content/full/574/1/7
  12. Semple RK, Chatterjee VK, Rahilly SO. PPAR and human metabolic disease. J. Clin. Invest. 2006;116:581-589
  13. Simopoulos AP. Evolutionary aspects of omega-3 fatty acids in the food supply. 
    Prostaglandins Leukot Essent Fatty Acids. 1999;60(5-6):421-9
  14. Simopoulos AP. The Mediterranean Diets: What Is So Special about the Diet of Greece? The Scientific Evidence. J. Nutr. 2001;131:3065S-3073S At http://jn.nutrition.org/cgi/content/full/131/11/3065S
  15. Eaton SB, Eaton SB. Paleolithic vs. modern diets – selected pathophysiological implications European Journal of Nutrition 2000;39(2):67-70
  16. Tommy Jönsson et al. A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs. Nutrition & Metabolism 2006;3:39 At http://nutritionandmetabolism.com/content/3/1/39
  17. Lindeberg S et al. Biological and Clinical Potential of a Palaeolithic Diet. Journal of Nutritional & Environmental Medicine 2003;13(3):149 - 160
  18. Eaton SB. Paleolithic nutrition revisited: A twelve-year retrospective on its nature and implications. Eur J Clin Nutr 1997;51:207-216 At http://www.nature.com/ejcn/journal/v51/n4/pdf/1600389a.pdf
  19. Cordain L et al. The paradoxical nature of hunter-gatherer diets: meat-based, yet non-atherogenic. Eur J Clin Nutr 2002;56(Suppl 1): S42–S52 At http://www.thepaleodiet.com/articles/Meat%20Paradox%20Final.pdf
  20. Eaton SB, Eaton SB. Evolution, Diet and Health At http://ecology.botany.ufl.edu/ecologyf03/downloads/PaleoDiet.pdf
  21. Manning R. Against the grain: How agriculture has hijacked civilization. North Point Press, New York. 2004
  22. Eaton SB, Nelson DA. Calcium in evolutionary perspective. Am J Clin Nutr 1991;54:281S-287S At http://www.ajcn.org/cgi/reprint/54/1/281S
  23. Giammattei J et al. Television Watching and Soft Drink Consumption- Associations With Obesity in 11- to 13-Year-Old Schoolchildren. Arch Pediatr Adolesc Med. 2003;157:882-886. At http://archpedi.ama-assn.org/cgi/content/full/157/9/882
  24. St-Onge MP, Keller KL, Heymsfield SB.Changes in childhood food consumption patterns: a cause for concern in light of increasing body weights. Am J Clin Nutr. 2003;78(6):1068-1073 At http://www.ajcn.org/cgi/content/full/78/6/1068
  25. French SA et al. Fast food restaurant use among adolescents: associations with nutrient intake, food choices and behavioral and psychosocial variables At http://www.nature.com/ijo/journal/v25/n12/full/0801820a.html
  26. McGartland C et al. Carbonated Soft Drink Consumption and Bone Mineral Density in Adolescence: The Northern Ireland Young Hearts Project At  http://www.jbmronline.org/doi/full/10.1359/jbmr.2003.18.9.1563
  27. Lopez-Garcia E. Consumption of Trans Fatty Acids Is Related to Plasma Biomarkers of Inflammation and Endothelial Dysfunction. J. Nutr. 2005;135:562-566 At http://jn.nutrition.org/cgi/content/full/135/3/562
  28. Ascherio A, Willett WC. Health effects of trans fatty acids. Am J Clin Nutr 66:1006S-1010S At http://www.ajcn.org/cgi/reprint/66/4/1006S
  29. Biochemistry in the news: trans fatty acids At http://www.people.umass.edu/ktheis/tfa.htm
  30. Golob J. King of the Nerds - Evil Kinked Fats At http://www.thestranger.com/seattle/Content?oid=267547
  31. Revealing trans fats At http://www.fda.gov/FDAC/features/2003/503_fats.html
  32. Jacobson MF. High-fructose corn syrup and the obesity epidemic. Am J Clin Nutr. 80(4):1081At http://www.ajcn.org/cgi/content/full/80/4/1081
  33. Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 79(4):537-543 At http://www.ajcn.org/cgi/content/full/79/4/537
  34. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ. Fructose, weight gain, and the insulin resistance syndrome. American Journal of Clinical Nutrition.  2002;76(5):911-922. At http://www.ajcn.org/cgi/content/full/76/5/911
  35. Cordain L. Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr 2005;81(2):341-354 At http://www.ajcn.org/cgi/content/full/81/2/341
  36. Burkitt DP, Eaton SB. Putting the wrong fuel in the tank. Nutrition. 1989; 5(3): 189-91 
  37. Weir GC, Weir SB. Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes. Diabetes 53:S16-S21, 2004 At http://diabetes.diabetesjournals.org/cgi/content/full/53/suppl_3/S16
  38. Pathogenesis and Natural History of Type 2 Diabetes http://www.medscape.com/viewarticle/432790
  39. Mark AL et al. Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications. J Hypertension. 2002;20(7):1245-1250.
  40. Friedman JM. Obesity in the new millennium At http://mcdb.colorado.edu/courses/4410/papers/fried_rev00.pdf
  41. Zimmet P et al. Etiology of the Metabolic Syndrome: Potential Role of Insulin Resistance, Leptin Resistance, and Other Players Ann NY Acad Scs 1999;892:25-44 At http://www.annalsonline.org/cgi/content/abstract/892/1/25
  42. Kennedy  et al. The Metabolic Significance of Leptin in Humans: Gender-Based Differences in Relationship to Adiposity, Insulin Sensitivity, and Energy Expenditure J Clin Endo Met 82(4):1293-1300 At http://jcem.endojournals.org/cgi/content/full/82/4/1293
  43. Kahn SE et al. Obesity, Body Fat Distribution, Insulin Sensitivity and Islet   b -Cell Function as Explanations for Metabolic Diversity J Nutr. 2001;131:354S-360S. At http://jn.nutrition.org/cgi/content/full/131/2/354S
  44. Cordain L, Eades MR, Eades MD.  Hyperinsulinemic diseases of civilization: more than just syndrome X. Comp Biochem Physiol Part A 2003;136:95-112. At http://thepaleodiet.com/articles/Hyperinsulinemic%20Diseases%20Final.pdf
  45. Reaven G. Metabolic Syndrome: Pathophysiology and Implications for Management of Cardiovascular Disease. Circulation. 2002;106:286
  46. Rao G. Insulin Resistance Syndrome. American Family Physician 2001;63(6) At http://www.aafp.org/afp/20010315/1159.html
  47. Kahn SE et al. Obesity, Body Fat Distribution, Insulin Sensitivity and Islet    -Cell Function as Explanations for Metabolic Diversity. Journal of Nutrition. 2001;131:354S-360S. At http://jn.nutrition.org/cgi/content/full/131/2/354S
  48. Hayden MR, Tyagi SC. Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: The pleiotropic effects of folate supplementation. Nutrition Journal 2004;3:4 At http://bmc.ub.uni-potsdam.de/1475-2891-3-4/1475-2891-3-4.pdf
  49. Després JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006;444:881-88
  50. Pittas AG, Joseph NA, Greenberg AS. Adipocytokines and Insulin Resistance. JCEM 89(2)447-452 At http://jcem.endojournals.org/cgi/content/full/89/2/447
  51. Aytekin et al. High-Sensitivity C-Reactive Protein in Patients with Metabolic Syndrome Angiology. 2006:57(3):295-302
  52. Ford ES et al. The Metabolic Syndrome and Concentrations of C-Reactive Protein Among U.S. Youth. Diabetes Care 2005;28:878-881 At http://care.diabetesjournals.org/cgi/content/full/28/4/878
  53. Berneis KK, Krauss RM. Metabolic origins and clinical significance of LDL heterogeneity. J Lipid Res. 2002;43:1363-1379.
  54. Ginsberg HN. Insulin resistance and cardiovascular disease J Clin Inv 2000;106(4):453-458 At http://www.jci.org/cgi/reprint/106/4/453.pdf
  55. Cruz AB et al. Effect of Intra-arterial Insulin on Tissue Cholesterol and Fatty Acids in Alloxan-Diabetic Dogs. Circulation Research. 1961;9:39 At http://circres.ahajournals.org/cgi/reprint/9/1/39
  56. Ginsberg HN Insulin resistance and cardiovascular disease. J Clin Invest. 2000;106(4):453-458 At http://www.jci.org/cgi/content/full/106/4/453
  57. Guido Arcaro G et al. Insulin Causes Endothelial Dysfunction in Humans- Sites and Mechanisms. Circulation. 2002;105:576. At http://circ.ahajournals.org/cgi/content/full/105/5/576
  58. Nishimoto Y et al. Enhanced secretion of insulin plays a role in the development of atherosclerosis and restenosis of coronary arteries: elective percutaneous transluminal coronary angioplasty in patients with effort angina. J Am Coll Cardiol. 1998;32:1624-1629 At http://content.onlinejacc.org/cgi/content/full/32/6/1624
  59. Ferrannini E, Haffner SM, Mitchell BD, Stern MP. Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome. Diabetologia. 1991;34(6)::416-422 Abstract At http://www.springerlink.com/content/q41268052426733h/
  60. Dieudonne MN et al. Leptin mediates a proliferative response in human MCF7 breast cancer cells. Biochemical and Biophysical Research Communications. 2002;293(1):622-628(7)
  61. Stattin P. Leptin Is Associated with Increased Prostate Cancer Risk: A Nested Case-Referent Study.  JCEM. 86(3):1341-1345
  62. Chang S et al. Leptin and prostate cancer. Prostate. 2001;46(1):62-7
  63. Park SY, Murphy SP, Wilkens LR et al.  Calcium, Vitamin D, and Dairy Product Intake and Prostate Cancer Risk: The Multiethnic Cohort Study. American Journal of Epidemiology 2007 166(11):1259-1269 At http://aje.oxfordjournals.org/cgi/content/abstract/166/11/1259
  64. Park Y, Mitrou PN, Kipnis V, Hollenbeck A, Schatzkin A, Leitzmann MF. Calcium, Dairy Foods, and Risk of Incident and Fatal Prostate Cancer: The NIH-AARP Diet and Health Study. American Journal of Epidemiology 2007 166(11):1270-1279 At http://aje.oxfordjournals.org/cgi/content/abstract/166/11/1270
  65. Venkateswaran V, Haddad AQ, Fleshner NE et al. Association of Diet-Induced Hyperinsulinemia With Accelerated Growth of Prostate Cancer (LNCaP) Xenografts. Journal of the National Cancer Institute 2007;99(23):1793-1800. At http://jnci.oxfordjournals.org/cgi/content/abstract/99/23/1793
  66. Leptin and its role in tumor progression At http://www.bioportfolio.com/LeadDiscovery/PubMed-060303.html
  67. Catalano S et al. Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line J Biol Chem. 2003;278(31):28668-76
  68. Mettlin C. Milk drinking, other beverage habits, and lung cancer risk. Int J Cancer. 1989;43(4):608-12
  69. Steinberg D. Obesity's Risks Include Cancer, Too. The Scientist. March 2003 At http://www.cnr.berkeley.edu/cwh/PDFs/news/obesity_risks_cancer_TheSci_3-03.pdf

  70. Bianchini Fet al. Overweight, obesity, and cancer risk. Lancet Oncol 2002;3:565-74.

  71. Giovannucci E. Insulin, Insulin-Like Growth Factors and Colon Cancer: A Review of the Evidence. J. Nutr. 2001;131:3109S-3120S
  72. Giovannucci E. Metabolic syndrome, hyperinsulinemia, and colon cancer: a review. American Journal of Clinical Nutrition, 2007;86(3): 836S-842S,. At http://www.ajcn.org/cgi/content/abstract/86/3/836S
  73. Hsu IR, Kim SP, Kabir M, Bergman RN. Metabolic syndrome, hyperinsulinemia, and cancer. American Journal of Clinical Nutrition 2007;86(3):867S-871S At http://www.ajcn.org/cgi/content/abstract/86/3/867S
  74. Stoll BA: Biological mechanisms in breast cancer invasiveness: relevance to preventive interventions. Eur J Cancer Prev 2000;9(2):73-9.
  75. Bruning PF, Bonfrer JM, van Noord PA, et al: Insulin resistance and breast cancer risk. Int J Cancer 1992;52:511-6.
  76. Del Giudice MF, Faulus IG, Ezzat S, et al: Insulin and related factors in premenopausal breast cancer risk. Breast Cancer Res Treat 1998;47:111-20.
  77. Stoll BA: Western nutrition and the insulin resistance syndrome: a link to breast cancer. Eur J Clin Nutr 1999:53:83-7.
  78. Yang G, Lu G, Jin F, et al: Population-based, case-control study of blood C-peptide level and breast cancer risk. Cancer Epidemiol Biornarkers Prev 2001;10:1207-11.
  79. Tripkovic I, Tripkovic A, Ivanisevic Z, Capkun V, Zekan L. Insulin increase in colon cancerogenesis: a case-control study Archives of Medical Research 2004;35(3):215-219 At http://www.sciencedirect.com/science
  80. Bruning PF et al. Insulin resistance and breast-cancer risk. Int J Cancer. 1992;52(4):511-6.
  81. McCance KL,  Jones RE. Estrogen and insulin crosstalk: Breast cancer risk implications. Nurse Practitioner  May 2003. At http://findarticles.com/p/articles/mi_qa3958/is_200305/ai_n9267963/pg_1
  82. Kim YI. Diet, lifestyle, and colorectal cancer: is hyperinsulinemia the missing link? Nutr Rev. 1998;56(9):275-9.
  83. Giovannucci E. Nutrition, Insulin, Insulin-like Growth Factors and Cancer Horm Metab Res 2003;35:694-704
  84. Yam D et al Hyperinsulinemia in colon, stomach and breast cancer patients. Cancer Lett. 1996;104(2):129-32.
  85. Giovannucci E. Insulin and colon cancer Cancer Causes and Control 1995;6(2):164-179
  86. Suehiro T et al. Hyperinsulinemia in patients with colorectal cancer. Hepatogastroenterology. 2005;52(61):76-8.
  87. Augustin LSA, Dal Maso L, LaVecchia C et al. Dietary glycemic index and glycemic load, and breast cancer risk: A case-control study Annals of Oncology 12 1533-1538.2001 At http://annonc.oxfordjournals.org/cgi/reprint/12/11/1533
  88. Sato M. Association between Serum Leptin Concentrations and Bone Mineral Density, and Biochemical Markers of Bone Turnover in Adult Men JCEM 86(11):5273-5276
  89. Matkovic V. Leptin Is Inversely Related to Age at Menarche in Human Females. JCEM 82(10):3239-3245
  90. Hegsted DM. Fractures, calcium, and the modern diet. Am J Clin Nutr 2001;74(5):571-573 At http://www.ajcn.org/cgi/content/full/74/5/571
  91. Livingstone C, Collison M. Sex steroids and insulin resistance Clinical Science. 2002;102:151–166 At http://www.clinsci.org/cs/102/0151/cs1020151.htm
  92. The Pathophysiology of Polycystic Ovary Syndrome at http://www.medscape.com/viewarticle/466573_2
  93. Petermann TS et al. Are circulating leptin and luteinizing hormone synchronized in patients with polycystic ovary syndrome? Hum Repro 1999;14(6):1435-1439 At http://humrep.oxfordjournals.org/cgi/content/full/14/6/1435
  94. Cordain L.  Dietary implications for the development of acne: a shifting paradigm. In: U.S. Dermatology Review II 2006, (Ed.,Bedlow, J). Touch Briefings Publications, London, 2006. At http://thepaleodiet.com/articles/Cordain%20US%20Dermatology%20Reviews.pdf
  95. Cordain L. Acne Vulgaris A Disease of Western Civilization. Arch Dermatol. 2002;138:1584-1590 At http://archderm.ama-assn.org/cgi/content/full/138/12/1584
  96. The Paleo Diet Newsletter 2006;2(4) At http://www.thepaleodiet.com/21
  97. Perheentupa J et al. Fructose-induced hyperuricaemia. Lancet 1967;2:52831.
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  102. Jacob S, Rett K, Henriksen EJ. Antihypertensive therapy and insulin sensitivity: do we have to redefine the role of beta-blocking agents? Am J Hypertens. 1998;11(10):1258-65.
  103. Lithell HO. Hyperinsulinemia, insulin resistance, and the treatment of hypertension. Am J Hypertens. 1996 Nov;9(11):150S-154S.
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  108. Does the lack of sleep make you fat? At http://www.bris.ac.uk/researchreview/2004/1113989409
  109. Sleep More to Fight Obesity At http://www.webmd.com/diet/news/20041116/sleep-more-to-fight-obesity
  110. Samaha FF. A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity. NEJM 2003;348(21):2074-2081
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  113. Volek JF et al. Fasting Lipoprotein and Postprandial Triacylglycerol Responses to a Low-Carbohydrate Diet Supplemented with n-3 Fatty Acids. J Amer Coll Nutr 2000;19(3):383-391 At http://www.jacn.org/cgi/content/full/19/3/383
  114. Meckling KA et al. Comparison of a Low-Fat Diet to a Low-Carbohydrate Diet on Weight Loss, Body Composition, and Risk Factors for Diabetes and Cardiovascular Disease in Free-Living, Overweight Men and Women. J Clin Endocrin Met 89(6):2717-2723 At http://jcem.endojournals.org/cgi/content/full/89/6/2717
  115. Brehm BJ et al. A Randomized Trial Comparing a Very Low Carbohydrate Diet and a Calorie-Restricted Low Fat Diet on Body Weight and Cardiovascular Risk Factors in Healthy Women. J Clin Endocrin Met 88(4):1617-1623 At http://jcem.endojournals.org/cgi/content/full/88/4/1617
  116. Kradjian RM. The Milk Letter: A Message To My Patients At http://www.notmilk.com/kradjian.html
  117. What's Wrong with Dairy Products? At http://www.pcrm.org/health/veginfo/dairy.html
  118. Another Reason Not To Drink Your Milk: Betacellulin Paleo Diet 2006;2:5 At http://thepaleodiet.com/newsletter/newsletters/PDNCourierVol2No5.pdf
  119. Occhipinti MJ. Does Milk Really Do The Body Good? Calcium and Protein: A Mixture for Disaster. At http://www.afpafitness.com/articles/?page_id=472
  120. Lorenz. Addition of milk prevents vascular protective effects of tea. European Heart Journal, doi:10.1093/eurheartj/ehl442
  121. Roberts HJ. Aspartame Disease: An FDA-approved Epidemic At http://www.aspartame.ca/epidemic-s3.pdf
  122. Lawler H, Wylet L. Aspartame: A Safe Sweetener? At http://www.pfamhealth.net/filecabinet/fall98aspartame.pdf
  123. Gold MD. Independent Analysis of the “Opinion of the European Commission, Scientific Committee on Food: Update on the Safety of Aspartame / E951” At http://www.holisticmed.com/aspartame/scf2002-response.rtf
  124. The Dangers Of Aspartame At http://www.healingcancernaturally.com/aspartame.rtf
  125. Lampe JW. Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies. Am J Clin Nutr 1999;70(3):475S-490S. At http://www.ajcn.org/cgi/content/full/70/3/475S
  126. New SA et al. Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health? Am J Clin Nutr 2000;71(1):142-151 At http://www.ajcn.org/cgi/content/full/71/1/142
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  128. Liu S et al. Fruit and vegetable intake and risk of cardiovascular disease: the Women's Health Study. Am J Clin Nutr 2000;72(4):922-928 At http://www.ajcn.org/cgi/content/full/72/4/922
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  137. Simopoulos AP. Essential fatty acids in health and chronic disease. Am J Clin Nutr 1999;70(3):560S-569S. At http://www.ajcn.org/cgi/content/full/70/3/560S
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  139. Enig MG, Fallon S.  The Oiling of America At http://www.nutritionaltherapycoop.com/The_Oiling_of_America.doc
  140. Kritchevsky SB. A Review of Scientific Research and Recommendations Regarding Eggs. J Am Coll Nutr 2004;23(90006, 596S-600S) Available at http://www.americanheart.org/presenter.jhtml?identifier=1226
  141. Li D et al. Lean meat and heart health. At http://www.healthyeatingclub.com/APJCN/Volume14/vol14.2/fullArticles/Li.pdf
  142. Elliott SS et al. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 2002;76(5):911-922 At http://www.ajcn.org/cgi/content/full/76/5/911
  143. Dietz WH, Gortmaker SL. Do We Fatten Our Children at the Television Set? Obesity and Television Viewing in Children and Adolescents. Pediatrics 1985;75(5):807-812
  144. Jeffery RW, French SA. Epidemic obesity in the United States: are fast foods and television viewing contributing? Am J Pub Health 88(2):277-280 At http://www.ajph.org/cgi/reprint/88/2/277
  145. O’Keefe JH, Gheewala NM, O’Keefe JO. Dietary Strategies for Improving Post-Prandial Glucose, Lipids, Inflammation, and Cardiovascular Health. J Am Coll Cardiol 2008; 51:249-255 Abstract at http://content.onlinejacc.org/cgi/content/abstract/51/3/249
  146. Barclay L, Vega C. Anti-Inflammatory" Diet May Improve Postprandial Glucose, Cardiovascular Health At http://www.medscape.com/viewarticle/569105
  147. Brehm BJ,  D'Alessio DA. Weight Loss and Metabolic Benefits With Diets of Varying Fat and Carbohydrate Content: Separating the Wheat From the Chaff. Nature Clinical Practice Endocrinology & Metabolism Available at http://www.medscape.com/viewarticle/569321
 

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